This is a notice of funding opportunity (NOFO) for the Comprehensive Opioid Stimulant and Substance Use Program (COSSUP) Training and Technical Assistance (TTA). This opportunity will provide training and technical assistance to BJA COSSUP grantees to address technical operational challenges to improve responses to overdose deaths, illicit opioids, stimulants, and other substances.
This funding opportunity announcement (FOA) encourages applications for institutional research career development (K12) programs that propose to support intensive supervised research training and career development experiences for clinician scientists (Scholars) leading to research independence in the area of substance use and substance use disorder research.
This is a notice of funding opportunity (NOFO) for the OJJDP FY 2026 Mentoring for Youth Impacted by Opioids and Other Substance Use program. This opportunity supports the implementation and delivery of high-quality mentoring services for youth who are currently using or dependent on substances, as well as youth at risk of substance use or who have close family members experiencing substance use or dependency. Mentoring services may include one-on-one, group, or peer mentoring - or a combination of these approaches or hybrid (traditional in-person combined with virtual mentoring).
Substance AbuseJustice and Juvenile JusticeYouth and At-Risk Youth
This is a notice of funding opportunity (NOFO) for the OJJDP FY 2026 Opioid Affected Youth Initiative. This NOFO supports states, localities, Tribal jurisdictions, and non-profit organizations in addressing violent crime and reducing overdose deaths through prevention, intervention, and treatment strategies to support children, youth, and families affected by opioid, stimulant, and other substance use disorders.
Applicants are expected to collaborate with law enforcement, juvenile and criminal justice agencies, schools, mental health and child welfare providers, community health agencies, and community-based organizations to address the needs of children, youth, and families who are at risk for or already in the child welfare or justice systems.
Substance AbuseJustice and Juvenile JusticeYouth and At-Risk Youth
This is a notice of funding opportunity (NOFO) for the BJA FY2026 Residential Substance Abuse Treatment (RSAT) for State Prisoners Formula Grants Program. This opportunity provides formula grant funding to enhance the capabilities of state, local, and tribal governments to support residential substance use disorder (SUD) treatment to adult and juvenile populations in detention or incarceration, initiate or continue evidence-based SUD treatment in jails, prepare individuals for reintegration into the community, and assist them and their communities throughout the reentry process by delivering community-based treatment and other recovery aftercare services. This NOFO will increase access to treatment for individuals with substance use or co-occurring substance use and mental health disorders in detention or incarceration and improve continuity of care during and after reentry by delivering community-based treatment and other broad-based aftercare services.
The Centers for Disease Control and Prevention’s (CDC) National Center for Injury Prevention and Control (NCIPC, Injury Center) is soliciting investigator-initiated research to develop, implement, and rigorously evaluate strategies to address and overcome barriers to implementing evidence-based linkage to care services in health care settings. Strategies should focus on individuals with opioid use disorder (OUD) or who meet criteria consistent with an OUD and are at risk of an opioid overdose with or without involvement of other substances.
Applicants are expected to have at least one partnership with a public health entity or bona fide agent to identify solutions to challenges in linkages to care. The proposed research should articulate how partnerships with public health entities were established or fostered. All applicants must also propose to collaborate with a local champion in a health care setting to improve linkage to care services and outcomes.
Outcomes can be captured by at least two required measures as defined in the NOFO.
Solutions are expected to be actionable approaches that can be adopted by clinicians and health systems in real-world settings and ensure availability of comprehensive overdose prevention services.
The National Institute on Drug Abuse (NIDA) invites applications to renew and expand the Collaboratory on Neural Ensembles and Used Substances (NExUS).
NExUS is a collaborative research program to decode how substance use experiences and addictive neurobehavioral states are represented in the brain at the level of cell populations.
This funding opportunity seeks applications that propose systematic and scalable methods to identify, map, and analyze groups of neurons that respond to used substances. The goal is to create a comprehensive, multimodal database and use it to test hypotheses about how specific neural population activity patterns relate to behavioral states associated with substance use and substance use disorders (SUD), including intoxication, craving, and dependence.
The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.
The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.
The purpose of the Rural Communities Opioid Response Program (RCORP) - Overdose Response is to support improving health care in rural areas by addressing their immediate and short-term needs related to the provision of substance use disorder services. RCORP Overdose Response aims to reduce and prevent the risk of overdoses in rural areas.
Community and Economic DevelopmentHealth and MedicalSubstance Abuse