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OpenFederal · Grants.gov

The Genesis Mission: Transforming Science and Energy with AI

Office of Science

Description

The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud. DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions). In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.

Award amount

$500,000 – $16,000,000

Total program funding: $293,760,000

Eligibility

See the funder's official page.

Who can apply: Individuals, Nonprofits, Small Businesses, For-Profit Businesses, Government & Tribal, Schools & Colleges

Location

Nationwide (USA)

Categories

EnergyResearch and EvaluationScienceTechnology

Funding source

Federal Government

Important dates

  • Opens: Mar 17, 2026
  • Deadline: Dec 17, 2026

How to apply

Apply through Grants.gov. Your organization needs active SAM.gov (UEI) and Grants.gov registrations, these can take several weeks, so start early.

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