National Institutes of Health
The National Biomedical Research Centers (NBRCs) are expected to provide scientific expertise, advanced equipment, infrastructure, and a range of well-characterized research models to researchers across the nation. Research at the NBRCs is supported by almost all NIH Institutes, as well as other federal agencies, including those that safeguard US national security interests. This NOFO emphasizes development of innovative human-based models and new technologies to reduce reliance on live research models. Applications must describe clear, actionable plans to reduce, refine, and replace whole-animal use by developing complementary and alternative approaches tailored to relevant use cases in biomedical research. Scientifically, the NBRCs function as centers of innovation in fundamental science as well as translational hubs that develop, refine, and test novel interventions for ultimate use in human patients. It is NIH’s intention that the NBRCs become leaders in the development and use of human-based approaches, including sophisticated in vitro and in silico models, known as New Approach Methodologies (NAMs). Clinical trials are allowed only as human-based NAMs, where applicable. This notice of funding opportunity (NOFO) is an open competition to increase opportunities for innovation, including NAMs research, at research centers with existing nonhuman primate colonies, and to further leverage existing capabilities in basic and translational research.
$7,955,376 – $11,405,967
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Who can apply: Schools & Colleges, Nonprofits, Small Businesses, Government & Tribal, For-Profit Businesses
Nationwide (USA)
Federal Government
This is a forecasted opportunity. Watch Grants.gov for the official notice; applications open once it is posted. You'll need SAM.gov (UEI) and Grants.gov registrations.
Substance Abuse and Mental Health Services Adminis
The purpose of this program is to support organizations in mobilizing and connecting community resources to increase access to long-term recovery support for people with substance use disorders and co-occurring substance use and mental disorders.
Last verified Oct 19, 2026
Centers for Disease Control and Prevention - ERA
The purpose of the R01 grant program is to (1) improve understanding of the risks and conditions associated with occupational diseases and injuries, (2) identify and evaluate methods to reduce risks and prevent or minimize exposure to hazardous workplace conditions, and (3) translate scientific findings into practical prevention strategies, interventions, and products that reduce work-related illnesses and injuries. The Research Project Grant (R01) supports a discrete, specified research project in scientific areas that reflect the investigator's expertise and interests and that align with the mission of NIOSH. Applicants must concisely describe the occupational health problem their proposal addresses and explain how the proposed research activities will lead to outputs that help address this problem. Applicants should clearly describe the expected impacts of the proposed research, both during the project period and beyond.
Last verified Oct 19, 2026
Office of Naval Research
Established in 1985, the Department of War Multidisciplinary University Research Initiative (MURI) program funds U.S. academic research teams to conduct high-impact basic research that addresses future challenges faced by the Department of War. The MURI program specifically supports U.S. university teams investigating complex, DoW-relevant problem sets at the intersection of multiple scientific disciplines. MURI teams bring together world-class faculty, postdoctoral researchers, and graduate students - helping to develop a technically advanced, defense-aware scientific workforce and strengthen the U.S. defense industrial base.
Last verified Oct 19, 2026
Centers for Disease Control and Prevention - ERA
This Notice of Funding Opportunity (NOFO) supports research to develop, implement, monitor, and evaluate technology-driven and cost-effective tools that reduce the global human rabies burden. It also measures progress toward canine rabies elimination, with an emphasis on high-burden countries. Priority research areas include: Electronic systems for tracking human and dog rabies vaccinations. Managing human rabies exposure investigations. Enhancing rabies laboratory information management systems. Modeling the economic impact of dog-mediated rabies interventions. Estimating rabies-susceptible dog populations. The research is intended to generate data-driven strategies that help accelerate progress toward global canine rabies elimination and protect public health.
Last verified Oct 19, 2026